This publication describes 23 programs that have been proven to help young people successfully complete high school and be prepared for success in postsecondary education and careers. These programs represent a wide range of interventions, including school-wide reform initiatives, community-based afterschool services, work-based learning opportunities, and college access programs. From an analysis of the included programs, the report identifies common programmatic and structural elements that may contribute to their effectiveness and summarizes key outcomes. The publication also sets forth a logic model that illustrates the complexity of the process for youth to develop the foundational knowledge, skills, abilities, and personal resources required for success in careers, lifelong learning, and civic engagement, as well as the various systems and service providers that support youth at each step of the developmental pipeline. The report concludes with policy recommendations on how policymakers can support college- and career-readiness for all students.